Tendons are strong, fibrous connective tissues that connect muscles to bones, allowing for the transmission of forces generated by muscle contractions to the skeletal system, resulting in movement. They play a crucial role in the musculoskeletal system, providing stability, support, and efficient force transfer.

Tendons are primarily composed of collagen fibers, specifically type I collagen, which provides them with their strength and flexibility. These collagen fibers are organized into parallel bundles, allowing tendons to resist tensile forces along the axis of the fibers. The extracellular matrix of tendons also contains proteoglycans, glycoproteins, and elastin fibers, which contribute to the overall structure and mechanical properties of the tendon.

Tendon cells, called tenocytes or tendon fibroblasts, are responsible for producing and maintaining the extracellular matrix. Tenocytes are elongated, spindle-shaped cells that are aligned along the collagen fibers, and they play a role in maintaining tendon homeostasis and repair.

Tendon injuries can occur due to overuse, acute trauma, or degenerative changes and can result in pain, inflammation, and loss of function. Common tendon injuries include tendinitis, tendinosis, and tendon ruptures. Treatment options for tendon injuries depend on the severity and location of the injury and may include rest, ice, compression, elevation, anti-inflammatory medications, physical therapy, or in more severe cases, surgery.

Similar to ligaments, tendons have a relatively poor blood supply, which can result in slow healing and a higher risk of re-injury. Research in tissue engineering and regenerative medicine is focused on developing novel approaches to improve tendon healing and regeneration, such as the use of stem cells, growth factors, or biomaterial scaffolds. These strategies may provide new therapeutic options for treating tendon injuries and improving musculoskeletal function.